481984

Nifuroxazide

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity.

• 同義詞: Nifuroxazide, 5-Nitro-2-furaldehyde- p-hydroxybenzoylhydrazone, 5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
• 經驗公式（希爾表示法）: C₁₂H₉N₃O₅
• CAS號碼: 965-52-6
• 分子量：: 275.22
• MDL號碼: MFCD00079482
• 分類程式碼代碼: 12352125
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: bright yellow
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: [N+](=O)([O-])c1[o]c(cc1)\C=N\NC(=O)c2ccc(cc2)O
• InChI: 1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
• InChI 密鑰: YCWSUKQGVSGXJO-NTUHNPAUSA-N

描述

一般說明

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC₅₀ = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-_κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC₅₀ = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC₅₀ = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-_κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC₅₀ = 10 µM against tyr⁷⁰⁵ of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser⁷²⁷ phosphorylation of STAT3.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他說明

Nelson, E.A., et al. 2008. Blood112, 5095.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3