474705

Mevastatin, Sodium Salt

Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.

• 同義詞: Mevastatin, Sodium Salt
• 經驗公式（希爾表示法）: C₂₃H₃₅O₆ · Na
• 分子量：: 430.51
• 分類程式碼代碼: 51111800
• NACRES: NA.77

屬性

• 品質等級: 200
• 化驗: ≥98% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: ethanol: 20 mg/mL; DMSO: 30 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays.

Carboxylate form of Mevastatin (Cat. No. 474700) that is active in whole cells and in cell-free assays. Mevastatin is an antibiotic that acts as a potent inhibitor of HMG-CoA reductase. Suppresses Ras farnesylation and inhibits myoblast fusion. Causes cell cycle arrest in late G₁ phase. Mevastatin may also induce bone morphogenic protein-2 (BMP-2).

生化／生理作用

Cell permeable: no

Primary Target
HMG-CoA reductase

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun.271, 88.
Endo, A. 1992. J. Lipid Res.33, 1569.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable