444288

MMP-2 Inhibitor III

The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 同義詞: MMP-2 Inhibitor III, (2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide
• 經驗公式（希爾表示法）: C₁₇H₂₀N₂O₅S
• CAS號碼: 704888-90-4
• 分子量：: 364.42
• MDL號碼: MFCD09971105
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: methanol: 100 mg/mL; DMSO: 200 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: [S](=O)(=O)(N(OC(C)C)CC(=O)NO)c1ccc(cc1)c2ccccc2
• InChI: 1S/C17H20N2O5S/c1-13(2)24-19(12-17(20)18-21)25(22,23)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13,21H,12H2,1-2H3,(H,18,20)
• InChI 密鑰: PHGLPDURIUEELR-UHFFFAOYSA-N

描述

一般說明

A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn²⁺-binding site-targeting inhibitor of MMP-2 (IC₅₀ = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC₅₀ = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC₅₀ >50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.

生化／生理作用

Cell permeable: yes

Primary Target
MMP-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 12 nM against MMP-2

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Tuccinardi, T., et al. 2006. Bioorg. Med. Chem.14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable