444274

MMP-2/MMP-9 Inhibitor IV

The MMP-2/MMP-9 Inhibitor IV, also referenced under CAS 292605-14-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 同義詞: MMP-2/MMP-9 Inhibitor IV, SB-3CT
• 經驗公式（希爾表示法）: C₁₅H₁₄O₃S₂
• CAS號碼: 292605-14-2
• 分子量：: 306.40
• MDL號碼: MFCD09836266
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 效力: 13.9 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 100 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: [S](=O)(=O)(CC3SC3)c1ccc(cc1)Oc2ccccc2
• InChI: 1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
• InChI 密鑰: LSONWRHLFZYHIN-UHFFFAOYSA-N

描述

一般說明

A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (K_i = 13.9 nM) and MMP-9 (K_i = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (K_i = 206 µM) MMP-3 (K_i = 15 µM), or MMP-7 (K_i = 96 µM).

生化／生理作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Krüger, A., et al. 2005. Cancer Res.65, 3523.
Kleinfeld, O., et al. 2001. J. Biol. Chem.276, 17125.
Brown, S., et al. 2000. J. Am. Chem. Soc.122, 6799.

法律資訊

Sold under license of U.S. Patent 6,703,415.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable