推薦產品
化驗
≥95% (SDS-PAGE)
品質等級
形狀
liquid
比活性
≥2.8 x 108 units/mg protein
≥5 x 106 units/mL
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
avoid repeated freeze/thaw cycles
技術
cell based assay: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−70°C
基因資訊
human ... IFNA1(3340)
一般說明
Research area: Immunoand cks
Interferons are cytokines secreted by mammalian cells. They are broadly divided into type I– interferon alpha (IFN-α) and interferon beta (IFN-β), type II – interferon-gamma (IFN-γ), and type III – interferon lambda (IFN-λ) based on their structure, function, and receptor specificity. Recombinant αA interferon is a hydrophobic protein belonging to the IFN-α family of proteins.
Interferons are cytokines secreted by mammalian cells. They are broadly divided into type I– interferon alpha (IFN-α) and interferon beta (IFN-β), type II – interferon-gamma (IFN-γ), and type III – interferon lambda (IFN-λ) based on their structure, function, and receptor specificity. Recombinant αA interferon is a hydrophobic protein belonging to the IFN-α family of proteins.
應用
Interferon alpha has been used to evaluate its effect on VSV (vesicular stomatitis virus) infection in pancreatic ductal adenocarcinoma (PDA) cell lines and study the relationship between type I IFNsignaling, resistance to VSV infection, and the JAK/STAT (Janus kinase/signal transducers and activators of transcription) signaling pathways in PDA cell lines. It has also been used to study the inhibitory effect of Morbillivirus V Proteins on Interferon Signaling Pathways.
生化／生理作用
Recombinant, human αA-interferon expressed in E. coli have antiviral, antiproliferative, antineoplastic, and immunomodulating properties. Recombinant interferon αA (IFN-αA) is used as the first line of treatment for hepatitis C. It also displays a great therapeutic potential with chronic viral hepatitis, polycythemia, leukemia, and various other malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer.
警告
毒性：标准处理（A）
單位定義
每毫升培养基的一单位干扰素将导致牛MDBK细胞对VSV诱导的细胞病变性效应的50%抑制。相对于人αA-IFN的NIH国际标准品确定单位。在含有至少0.1%BSA或HSA的水性缓冲液中稀释。
外觀
在含0.1% BSA的PBS中。
準備報告
仅在含蛋白的缓冲液（例如0.1%BSA）中稀释。
重構
初次解冻后，分装冻存（-70°C）。
其他說明
Fujishima, H., et al. 1998.Int. J. Cancer 76, 423.
Haria, M., and Benfield, P. 1995.Drugs 50, 873.
Familletti, P.C., et al. 1981.Methods Enzymol.78, 387.
Haria, M., and Benfield, P. 1995.Drugs 50, 873.
Familletti, P.C., et al. 1981.Methods Enzymol.78, 387.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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