400084

HIF Prolyl Hydroxylase Inhibitor

• 同義詞: HIF Prolyl Hydroxylase Inhibitor
• 經驗公式（希爾表示法）: C₂₁H₁₆ClN₃O
• CAS號碼: 385786-48-1
• 分子量：: 361.82
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥95% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: tan
• 溶解度: DMSO: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC₅₀ = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC₅₀ = 0.25 µM in an oxidative stress model using cortical neurons.

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Smirnova, N.A., et al. 2010. Chem. Biol.4, 380.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable