400076-M

Hypericin

Polycyclic dione that has anti-retroviral activity.

• 同義詞: Hypericin, Casein Kinase II Inhibitor XI
• 經驗公式（希爾表示法）: C₃₀H₁₆O₈
• CAS號碼: 548-04-9
• 分子量：: 504.44
• MDL號碼: MFCD00016683
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: black
• 溶解度: ethanol: 1 mg/mL; methanol: 1 mg/mL; DMSO: 10 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3
• InChI 密鑰: BTXNYTINYBABQR-UHFFFAOYSA-N

描述

一般說明

Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC₅₀ = 3.3 µM). Also known to inhibit the protein tyrosine kinase activities of the insulin receptor (IC₅₀ = 20-29 nM), the epidermal growth factor receptor (IC₅₀ = 35 nM), casein kinase II (IC₅₀ = 6 nM), and MAP kinase (IC₅₀ = 4 nM). Useful probe for PKC due to its bright red fluorescence emission and photostability. Also see Pseudohypericin (Cat. No. 539590).

Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC₅₀ = 3.3 μM). Also known to inhibit casein kinase II (IC₅₀ = 6 nM), MAP kinase (IC₅₀ = 4 nM), and the protein tyrosine activities of the insulin receptor (IC₅₀ = 20-29 nM) and the epidermal growth factor receptor (IC₅₀ = 35 nM).

生化／生理作用

Primary Target
PKC

Target IC₅₀: 3.3 µM, 6 nM, 4 nM, 20-29 nM , 35 nM, against protein kinase C, casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor, and the epidermal growth factor receptor, respectively

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Zhang, W., et al. 1997. Cancer Lett.120, 31.
Agostinis, P., et al. 1995. Biochem. Pharmacol.49, 1615.
Frew, T., et al. 1994. Anticancer Res.14, 2425.
Barnard, D.L., et al. 1992. Antiviral Res.17, 63.
Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun.165, 1207.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable