400015

Caspase-1 Inhibitor IV

The Caspase-1 Inhibitor IV, also referenced under CAS 154674-81-4, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

• 同義詞: Caspase-1 Inhibitor IV, ICE Inhibitor IV, Ac-YVAD-AOM
• 經驗公式（希爾表示法）: C₃₃H₄₂N₄O₁₀
• CAS號碼: 154674-81-4
• 分子量：: 654.71
• MDL號碼: MFCD00798794
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥96% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated
• 顏色: white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: N([C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)COC(=O)c2c(cccc2C)C)C(=O)[C@@H](NC(=O)C)Cc1ccc(cc1)O
• InChI: 1S/C33H42N4O10/c1-17(2)29(37-31(44)25(35-21(6)38)14-22-10-12-23(39)13-11-22)32(45)34-20(5)30(43)36-24(15-27(41)42)26(40)16-47-33(46)28-18(3)8-7-9-19(28)4/h7-13,17,20,24-25,29,39H,14-16H2,1-6H3,(H,34,45)(H,35,38)(H,36,43)(H,37,44)(H,41,42)/t20-,24-,25-,29-

描述

一般說明

A highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

Highly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

生化／生理作用

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Ac-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)

重構

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable