397100

HNMPA-(AM)₃

A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases.

• 同義詞: HNMPA-(AM)₃, Hydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II
• 經驗公式（希爾表示法）: C₂₀H₂₃O₁₀P
• CAS號碼: 120944-03-8
• 分子量：: 454.36
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (TLC)
• 形狀: oil
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: colorless
• 溶解度: DMSO: 20 mg/mL; ethanol: 20 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases. Inhibits insulin receptor tyrosine kinase (IC₅₀ = 100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC₅₀ = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC₅₀ = 200 µM).

A cell-permeable analog of HNMPA. Inhibits insulin receptor tyrosine kinase (IC₅₀ = 100 mM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC₅₀ = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC₅₀ = 200 µM). It has no effect on PKA (at concentrations up to 1 mM) or PKC (at concentrations up to 420 µM).

生化／生理作用

Cell permeable: yes

Primary Target
tyrosine kinase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 µM and 10 µM against insulin receptor tyrosine kinase and insulin-stimulated glucose oxidation in isolated rat adipocytes, respectively

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Baltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA89, 7885.
Saperstein, R., et al. 1989. Biochemistry28, 5694.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable