推薦產品
產品名稱
组蛋白乙酰转移酶p300抑制剂，C646, Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes with acetyl-CoA for the p300 Lys-CoA binding pocket.
品質等級
化驗
≥99% (sum of isomers, HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
brick red
溶解度
DMSO: 50 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
InChI 密鑰
HEKJYZZSCQBJGB-UNOMPAQXSA-N
一般說明
一种可逆、细胞可渗透吡唑啉酮p300/CBP HAT抑制剂（Ki = 400 nM），可与乙酰辅酶A竞争p300 Lys-CoA结合袋。该化合物在10 nM处对p300有86%的抑制作用，但在化学筛选测定中对羟色胺N-乙酰转移酶、PCAF组蛋白乙酰转移酶、GCN5组蛋白乙酰转移酶、Rtt109组蛋白乙酰转移酶、Sas组蛋白乙酰转移酶以及MOZ组蛋白乙酰转移酶的抑制作用均小于10%。使用25µ M化合物处理C3H 10T1/2小鼠成纤维细胞可对组蛋白H3和H4的基础和TSA诱导乙酰化产生抑制效果。研究还表明，与25 µM基于多肽双底物p300/CBP HAT抑制剂Lys-CoA-Tat相比，10µM时可抑制黑色素瘤和非小细胞肺（NSCL）癌细胞系中人类细胞生长，并且具有相似或更高的药效。
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
复溶后，分装并冷冻保存（-20°C。储备液在-20°C条件下可稳定保存3个月。
其他說明
Bowers, EM., et al. 2010.Chem Biol17, 471.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Api5, is a known anti-apoptotic and nuclear protein that is responsible for inhibiting cell death in serum-starved conditions. The only known post-translational modification of Api5 is acetylation at lysine 251 (K251). K251 acetylation of Api5 is responsible for maintaining its
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Development can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant development, and potential epigenetic memory, remain unknown.
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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