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重要文件

371958

Sigma-Aldrich

H-8, Dihydrochloride

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases.

同義詞:

H-8, Dihydrochloride, N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I

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About This Item

經驗公式(希爾表示法):
C12H15N3O2S · 2HCl
CAS號碼:
分子量::
338.25
MDL號碼:
分類程式碼代碼:
12352200

品質等級

化驗

>95% (TLC)

形狀

lyophilized

製造商/商標名

Calbiochem®

儲存條件

OK to freeze

溶解度

water: 10 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI 密鑰

RJJLZYZEVNCZIW-UHFFFAOYSA-N

一般說明

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits protein kinase A (Ki = 1.2 µM), myosin light chain kinase (Ki = 68 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
A potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (Ki = 68 µM), protein kinase A (Ki = 1.2 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 68 µM against MLCK

警告

Toxicity: Standard Handling (A)

準備報告

Further dilute with aqueous buffer just prior to use.

其他說明

Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577.
Hidaka, H., et al. 1984. Biochemistry23, 5036.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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