361552

GSK-3 Inhibitor IX

InSolution, ≥97%

• 同義詞: InSolution GSK-3 Inhibitor IX
• 經驗公式（希爾表示法）: C₁₆H₁₀BrN₃O₂
• CAS號碼: 667463-62-9
• 分子量：: 356.17
• MDL號碼: MFCD08705318
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C

描述

一般說明

A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Specificity was confirmed using various Cdk′s (IC₅₀ = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC₅₀ ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).

生化／生理作用

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target IC₅₀: 5 nM against GSK-3α/β

包裝

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

外觀

A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.

其他說明

Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935.
Sato, N., et al. 2004. Nat. Med.10, 55.
Meijer, L., et al. 2003. Chem. Biol.10, 1255.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 188.6 °F
• 閃點（°C）: 87 °C