317642

Dipeptidylpeptidase IV Inhibitor IV, K579

The Dipeptidylpeptidase IV Inhibitor IV, K579, also referenced under CAS 440100-64-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 同義詞: Dipeptidylpeptidase IV Inhibitor IV, K579, (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV
• 經驗公式（希爾表示法）: C₁₇H₂₄N₆O
• CAS號碼: 440100-64-1
• 分子量：: 328.41
• MDL號碼: MFCD07364044
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white to light brown
• 溶解度: 1 M HCl: 16 mg/mL; DMSO: 32 mg/mL; ethanol: 6.5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: N3([C@@H](CCC3)C#N)C(=O)CNC1(CCN(CC1)c2ncccn2)C
• InChI: 1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1
• InChI 密鑰: JERPHRNGJBSFAP-AWEZNQCLSA-N

描述

一般說明

A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC₅₀ = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.

Takasaki, K., et al. 2004. Eur. J. Pharmacol.505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci.95, 291.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable