317641

Dipeptidylpeptidase IV Inhibitor III

The Dipeptidylpeptidase IV Inhibitor III, also referenced under CAS 866396-34-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 同義詞: Dipeptidylpeptidase IV Inhibitor III, 1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
• 經驗公式（希爾表示法）: C₁₄H₂₀N₄O₂ · xHCl
• CAS號碼: 866396-34-1
• 分子量：: 276.33 (free base basis)
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: PBS: 20 mg/mL; ethanol: 20 mg/mL; water: 20 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

描述

一般說明

An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC₅₀ = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Wright, S.W., et al. 2006. J. Med. Chem.49, 3068.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable