239819

CXCR2 antagonist, Cpd 19

The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2.

• 同義詞: CXCR2 antagonist, Cpd 19, 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
• 經驗公式（希爾表示法）: C₁₈H₂₁N₃O₄
• CAS號碼: 473728-67-5
• 分子量：: 343.38
• 分類程式碼代碼: 12352200
• NACRES: NA.51

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 50 mg/mL, light brown
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC₅₀ = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC₅₀ = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37^°C).

包裝

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett.16, 4107.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable