23-032-M

MDM2/CK1δ Protein, active, 10 µg

Active, full length, recombinant human MDM2 (N-terminal GST-tagged) combined in vitro with CK1δ, active (Item # 14-520). For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

• 同義詞: Double minute 2 protein, p53-binding protein Mdm2, Hdm2
• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

屬性

• 生物源: human
• 品質等級: 300
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable
• GenBank登錄號: AF527840

描述

一般說明

MDM2 is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumour suppressor protein and notably MDM2 itself. The suppression of p53 activity by an amplified Mdm2 gene has been observed in many tumours, including soft tissue sarcomas, osteosarcomas and breast tumours.

N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli.

應用

Ubiquitination Cascade Comoponent: E3

外觀

Purified using glutathione sepharose followed by gel filtration.

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

GenBank is a registered trademark of United States Department of Health and Human Services

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable