217714
5-氨基-3-((4 -(氨基磺酰基)苯基)氨基)-N-(2,6-二氟苯基)-1H-1,2,4-三唑-1-硫代乙酰胺
The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
同義詞:
5-氨基-3-((4 -(氨基磺酰基)苯基)氨基)-N-(2,6-二氟苯基)-1H-1,2,4-三唑-1-硫代乙酰胺, 5-氨基-3-((4-(磺酰胺)苯基)氨基)-N-(2,6-二氟苯基)-1H-1,2,4-三唑-1-硫代酰胺
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About This Item
推薦產品
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
DMSO: 10 mg/mL
THF: soluble
acetone: soluble
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
InChI 密鑰
ARIOBGGRZJITQX-UHFFFAOYSA-N
一般說明
一种可渗透细胞的三唑并二胺化合物,在各种人类癌细胞中均具有抗增殖特性(HCT-116,HeLa和A375细胞的IC50分别为20 nM,35 nM和92 nM)。作为Cdk1/细胞周期蛋白B和Cdk2/细胞周期蛋白A(IC50分别为600 pM和500 pM)的高效,可逆,ATP竞争性抑制剂,对VEGF-R2(IC50=32 nM),GSK-3β(IC50=140 nM)和一组其他八种激酶(IC50 ≥ 1 µM)具有选择性。
生化/生理作用
主要靶标
Cdk1/细胞周期蛋白B,Cdk2/细胞周期蛋白A
Cdk1/细胞周期蛋白B,Cdk2/细胞周期蛋白A
产物与ATP竞争。
可逆性:是
细胞可渗透性:是
靶标IC50:对于HCT-116,HeLa和A375细胞的抗增殖特性,分别为20 nM,35 nM和92 nM;针对Cdk1/细胞周期蛋白B和Cdk2/细胞周期蛋白A,分别为600 pM和500 pM
包裝
用惰性气体包装
警告
毒性:有害(C)
重構
复溶后,等分并冷冻保存(-20°C)。储备液在-20°C条件下可稳定保存6个月。
其他說明
Lin, R., et al. 2005.J.Med. Chem.48, 4208.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
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