208920

Calmodulin Kinase IINtide

A potent and specific inhibitor of CaMK II (IC₅₀ = 50 nM for both the total and Ca²⁺-independent CaMK II activity).

• 同義詞: Calmodulin Kinase IINtide, KRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
• 經驗公式（希爾表示法）: C₁₃₆H₂₄₀N₄₄O₃₉
• 分子量：: 3115.63
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: off-white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

A potent and specific inhibitor of CaMK II (IC₅₀ = 50 nM for both the total and Ca²⁺-independent CaMK II activity). Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC₅₀ range 100-400 nM). Does not affect the activities of CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of CaMK IIN.

A potent and specific inhibitor of calmodulin kinase II (CaM-KII) (IC₅₀ = 50 nM for both total and Ca²⁺-independent activities of CaM-KII). Does not affect the activities of CaM-KI, CaM-KIV, CaM-KK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of the inhibitory protein, CaM-KIIN. A cell-permeable version is available under Cat. No. 208921.

生化／生理作用

Cell permeable: no

Primary Target
Cam Kinase-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 nM for both the total and Ca2+-independent CaMK II activity

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

H-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH

外觀

Supplied as a trifluoroacetate salt.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

其他說明

Soderling, T.R., et al. 2001. J. Biol. Chem.276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA95, 13272.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable