197900

BEC, Hydrochloride

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5).

• 同義詞: BEC, Hydrochloride, (S)-(2-Boronoethyl)-L-cysteine, HCI)
• 經驗公式（希爾表示法）: C₅H₁₂BNO₄S · xHCl
• 分子量：: 193.03 (free base basis)
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥97% (NMR)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: water: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.

生化／生理作用

Cell permeable: no

Primary Target
arginase 1, arginase 2

Product does not compete with ATP.

Reversible: no

Target K_i: 310 nM for human recombinant type II arginase, pH 7.5

包裝

Packaged under inert gas

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.

其他說明

Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.
Kim, N.N., et al. 2001. Biochemistry40, 2678.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3