191501

1-Azakenpaullone

InSolution, ≥94%, ATP-competitive inhibitor of GSK-3Beta

• 同義詞: InSolution 1-Azakenpaullone
• 經驗公式（希爾表示法）: C₁₅H₁₀BrN₃O
• CAS號碼: 676596-65-9
• 分子量：: 328.16
• MDL號碼: MFCD09037522
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥94% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• InChI: 1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
• InChI 密鑰: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

描述

一般說明

A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC₅₀ = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.

生化／生理作用

Cell permeable: yes

Primary Target
GSK-3β

Reversible: yes

Target IC₅₀: 18 nM for GSK-3&beta

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.

重構

Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.

其他說明

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 188.6 °F - (refers to pure substance)
• 閃點（°C）: 87 °C - (refers to pure substance)