182015

Cyclo(Arg-Gly-Asp-D-Phe-Val)

Potent inhibitor of cell adhesion.

• 同義詞: Cyclo(Arg-Gly-Asp-D-Phe-Val), RGDFV Peptide, Cyclic
• 經驗公式（希爾表示法）: C₂₆H₃₈N₈O₇
• CAS號碼: 137813-35-5
• 分子量：: 574.63
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: 1 N acetic acid: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.

生化／生理作用

Cell permeable: no

Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

其他說明

Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable