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Merck
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重要文件

14-404-M

Sigma-Aldrich

ZAP-70 Protein, active, 20 µg

Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.

同義詞:

70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase

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About This Item

分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.32

生物源

human

品質等級

重組細胞

expressed in Sf21 cells

形狀

liquid

儲存期限

6 mo.

分子量

Mw 70 kDa

製造商/商標名

Upstate®

技術

activity assay: suitable (kinase)

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... ZAP70(7535)

一般說明

Research area: CELL SIGNALING

Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag

Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.

生化/生理作用

Protein Target: ZAP-70

Target Sub-Family: TK

Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.

品質

routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide

外觀

Ni2+/NTA-agarose

儲存和穩定性

6 months at -20C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1


分析證明 (COA)

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D H Chu et al.
Immunological reviews, 165, 167-180 (1998-12-16)
The processes of T-cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signaling molecules are shared between the receptor signaling pathways, including two families of cytoplasmic protein

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