1.37159

DL-二硫苏糖醇

EMPROVE^® ESSENTIAL

• 同義詞: 1,4-二巯基苏糖醇, DTT, 克莱兰氏试剂
• 線性公式: HSCH₂CH(OH)CH(OH)CH₂SH
• CAS號碼: 3483-12-3
• 分子量：: 154.25
• Beilstein: 1719757
• MDL號碼: MFCD00004877
• 酶委員會索引編號: 222-468-7

屬性

• 生物源: synthetic
• 品質等級: 500
• 產品線: EMPROVE^® ESSENTIAL
• mp: 41-44 °C (lit.)
• 應用: pharma/biopharma processes
• 儲存溫度: −20°C (−15°C to −25°C)
• SMILES 字串: O[C@H](CS)[C@H](O)CS
• InChI: 1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
• InChI 密鑰: VHJLVAABSRFDPM-QWWZWVQMSA-N

描述

一般說明

Our SAFC^® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.
M-Clarity Program
As part of our Emprove^® Program, our raw materials are offered with Emprove^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.
Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

應用

DTT is an excellent reagent chemical used to reduce disulfide bonds commonly found in bioprocessing. DTT is used in buffer formulations to maintain and stabilize free -SH in applications such as protein based biotherapeutics and enzyme stability.

用于将 −SH 基保持在还原态的绝佳试剂；定量还原二硫化物。在 SDS-PAGE 前，DTT 在样品缓冲液中可有效还原蛋白二硫键。DTT 还可用于还原交联剂 N,N′-双(丙烯酰)胱胺的二硫键桥以分解聚丙烯酰胺凝胶基质。DTT 的刺激性和毒性都低于 2-巯基乙醇。通常，使用 DTT (100mM) 所需的浓度是使用 2-巯基乙醇 (5% v/v, 700mM) 的浓度的七分之一。

包裝

1.37159.0010 / 10 g / Amber glass bottle
1.37159.0100 / 100 g / Amber glass bottle
1.37159.1000 / 1 kg / LDPE bag with outer HDPE drum
1.37159.9010 / 10 kg / LDPE bag with outer HDPE drum

法律資訊

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC Pharma is a registered trademark of Sigma-Aldrich Co. LLC

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H302 - H315 - H318
• 防範說明: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• 危險分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable