特異性
ADAP/SLAP-130/Fyb
免疫原
对应于小鼠Fyn 结合蛋白氨基酸755-768的合成肽（ADAP/SLAP-130/Fyb）。
應用
抗-ADAP/SLAP-130/Fyb抗体是针对ADAP/SLAP-130/Fyb的抗体，用于WB & IP。
研究子类别
免疫信号传导
激酶&磷酸酶
免疫信号传导
激酶&磷酸酶
研究类别
信号传导
信号传导
品質
通过免疫印迹对RAW 264.7巨噬细胞的RIPA裂解液进行了常规评估
標靶描述
130kDa
外觀
0.1M Tris-甘氨酸，pH 7.4，0.15M NaCl，0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
纯化蛋白A
儲存和穩定性
在-20°C下可保存2年
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Rajasekaran, K; Kumar, P; Schuldt, KM; Peterson, EJ; Vanhaesebroeck, B; Dixit, V; Thakar et al.
Nature Immunology null
A J Hunter et al.
Journal of immunology (Baltimore, Md. : 1950), 164(3), 1143-1147 (2000-01-21)
The role of integrin-mediated signaling events in T cell function remains incompletely characterized. We report here that alpha4beta1 integrin stimulation of H9 T cells and normal human T cell blasts results in rapid and transient tyrosine phosphorylation of the adapter
L Geng et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(20), 11527-11532 (2001-09-13)
Aggregation of the high-affinity IgE receptor (FcepsilonRI) on mast cells activates a tyrosine phosphorylation cascade that is required for adhesion and degranulation events leading to the release of histamine and other inflammatory mediators. The full range of intracellular mediators that
N J Boerth et al.
The Journal of biological chemistry, 275(7), 5143-5152 (2000-02-15)
T cell antigen receptor (TCR) engagement results in protein-tyrosine kinase activation which initiates signaling cascades leading to induction of the interleukin-2 gene. Previous studies identified two substrates of the TCR-induced protein-tyrosine kinases, SH2 domain-containing leukocyte specific protein of 76 kDa
Chunyang Li et al.
EMBO molecular medicine, 7(6), 754-769 (2015-04-09)
PD-1 negatively regulates CD8(+) cytotoxic T lymphocytes (CTL) cytotoxicity and anti-tumor immunity. However, it is not fully understood how PD-1 expression on CD8(+) CTL is regulated during anti-tumor immunotherapy. In this study, we have identified that the ADAP-SKAP55 signaling module
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