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重要文件

07-532

Sigma-Aldrich

抗磷酸化PKR (Thr446) 抗体

Upstate®, from rabbit

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

human

製造商/商標名

Upstate®

技術

western blot: suitable

同型

IgG

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

phosphorylation (pThr446)

基因資訊

human ... EIF2AK2(5610)

特異性

磷酸化PKR

免疫原

对应于人PKR的Thr446周围氨基酸的肽

應用

抗磷酸化Brk(Thr446)抗体是针对磷酸化PKR(Thr446)的抗体,可用于WB。
研究子类别
细胞骨架信号转导
研究类别
信号传导

品質

通过免疫印迹对HeLa细胞的RIPA裂解液进行了常规评估,HeLa细胞以IFN-α刺激过夜,然后以花萼海绵体诱癌素(calyculin)处理15分钟。

標靶描述

68 kDa

外觀

0.1M Tris-甘氨酸,pH 7.4,0.15M NaCl,0.05%叠氮化钠,然后添加甘油至30%
形式:纯化
纯化蛋白A

儲存和穩定性

在-20°C下可保存2年

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1


分析證明 (COA)

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X Saelens et al.
The Journal of biological chemistry, 276(45), 41620-41628 (2001-09-14)
The protein kinase PKR is a major player in the cellular antiviral response, acting mainly by phosphorylation of the alpha-subunit of the eukaryotic translation initiation factor 2 (eIF2-alpha) to block de novo protein synthesis. PKR activation requires binding of double-stranded
Dario Paolo et al.
Plants (Basel, Switzerland), 10(2) (2021-01-28)
Seed size is the result of complex molecular networks controlling the development of the seed coat (of maternal origin) and the two fertilization products, the embryo and the endosperm. In this study we characterized the role of Arabidopsis thaliana MADS-domain
Ka-Chun Suen et al.
The Journal of biological chemistry, 278(50), 49819-49827 (2003-09-17)
One of the hallmarks of Alzheimer's disease is extracellular accumulation of senile plaques composed primarily of aggregated beta-amyloid (Abeta) peptide. Treatment of cultured neurons with Abeta peptide induces neuronal death in which apoptosis is suggested to be one of the
Shien Hu et al.
Gastroenterology, 133(6), 1893-1904 (2007-12-07)
Inducible heat shock proteins (iHsp), Hsp25/27 and Hsp70, play essential roles in protecting cells against stress and, in intestinal mucosal inflammation, potentially lessening the extent and severity of injury. We examined the expression and regulation of iHsp in human and
Shuen-Ing Tschen et al.
Diabetes, 58(6), 1312-1320 (2009-02-21)
The aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass. We analyzed the capacity of beta-cell expansion in 1.5- and 8-month-old mice in response to a high-fat diet, after

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