07-261-I

Anti-mGluR2 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: 07-261, Histone H2AX, H2a/x, Histone H2A.X
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: rat
• 物種活性（以同源性預測）: mouse (based on 100% sequence homology)
• 技術: immunoprecipitation (IP): suitable; western blot: suitable
• NCBI登錄號: NP_001153825
• UniProt登錄號: Q14BI2
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Grm2(108068) ; rat ... Grm2(24415)

描述

一般說明

The metabotropic glutamate receptors belong to a family of G protein-coupled receptors that have been divided into 3 groups based on their sequence homology, putative signal transduction mechanisms, and pharmacologic properties. mGluR2 belongs to the Group II. It is widely expressed in different regions of fetal and the adult brain. Ligand binding to GluR2 induces a conformation change in the receptor, which triggers signaling to modulate the activity of down-stream effectors, mainly via the inhibition of adenylate cyclase activity. Activation of mGluR2 leads to inhibition of glutamate release at the synaptic junction

免疫原

Epitope: Cytoplasmic domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of mouse mGlur2.

應用

Anti-mGluR2 Antibody is an antibody against mGluR2 for use in Western Blotting, Immunoprecipitation.

Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated mGlur2 in 500 µg of rat brain microsomal prep.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

品質

Evaluated by Western Blotting in rat brain microsomal prep.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected mGlur2 in 10 µg of rat brain microsomal prep.

標靶描述

~95/200 kDa observed. The lower band corresponds to the calculated molecular weight of mGluR2 (~100 kDa) and the upper band is likely a receptor dimer and frequently appears in immunoblots of mGluRs (Reid and Romano, 2001; Romano et al., 1996).

聯結

Replaces: 07-261

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable