07-2262

Anti-WNK3 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: WNK lysine deficient protein kinase 3, serine/threonine-protein kinase WNK3, Protein kinase with no lysine 3, Protein kinase lysine-deficient 3, protein kinase, lysine deficient 3
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human, mouse
• 技術: western blot: suitable
• NCBI登錄號: NP_001002838
• UniProt登錄號: Q9BYP7
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... WNK3(65267)

描述

一般說明

WNK3 is a serine-threonine protein kinase and expressed throughout the nephron, but most commonly at intercellular junctions. In its active state, it is a promoter of NKCC2 and NCC activity. The opposite is true of WNK3 when in an inactive state. WNK3 changes the expression of these transporters in the membrane and is thought to be a regulator of blood pressure along with other members of the WNK family of protein kinases. In recent research, WNK3 has also been linked to regulating signaling cascades involved in tumorigenesis.

特異性

Other homologies: Rat (74% sequence homology).

免疫原

GST-tagged recombinant protein corresponding to human WNK3.

應用

Research Category
Signaling

Research Sub Category
Developmental Signaling

This WNK3 antibody is validated for use in WB for the detection of the WNK3 protein.

品質

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected WNK3 on 10 µg of HEK293 cell lysate.

標靶描述

~220 kDa observed. Uncharacterized bands appear at ~52 and 60 kDa

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
HEK293 cell lysate

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable