07-1601

Anti-IRAK1 Antibody, CT

from rabbit

• 同義詞: interleukin-1 receptor-associated kinase 1, Pelle homolog
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: human
• 技術: western blot: suitable
• NCBI登錄號: NP_001020413.1
• UniProt登錄號: P51617
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... IRAK1(3654)

描述

一般說明

IRAK1, also known as Interleukin-1 receptor associated kinase 1, belongs to the tyrosine kinase related (TKL) family and is involved with mRNA stabilization and activation of NF-kappa B. IRAK1 is located in all tissue as 2 isoforms, with 1 binding quickly and then degrading while isoform 2 is activated by kinase, resulting in a slower more sustained response to cytokines. Phosphorylation of IRAK1 leads to recruitment of the adapter protein PELI1. IRAK1 utilizes 2 pathways, the first one allows for mediation of IL-1 inflammatory responses when TRAF6 is bound, which activates NF-kappa B, thereby inhibiting I kappa B alpha. A second pathway does not involve TRAF6 and results in the stabilization of mRNA.

特異性

This antibody recognizes the C-terminal region of IRAK1.

免疫原

Epitope: C-terminus

KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of IRAK1.

應用

Research Category
Inflammation & Immunology

Research Sub Category
Immunological Signaling

This Anti-IRAK1 Antibody, C-terminus is validated for use in WB for the detection of IRAK1.

品質

Evaluated by western blot in jurkat lysate.

Western Blot Analysis: A 1:50-1:500 dilution of this antibody detected IRAK1 on jurkat lysate.

標靶描述

~77 kDa

外觀

Protein G Purified

Format: Purified

Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.

儲存和穩定性

Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析報告

Control
Jurkat lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable