07-1386

Anti-Connective Tissue Growth Factor Antibody

from goat

• 同義詞: Hypertrophic chondrocyte-specific protein 24, connective tissue growth factor, insulin-like growth factor-binding protein 8
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: goat
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: human
• 技術: western blot: suitable
• NCBI登錄號: NP_001892.1
• UniProt登錄號: P29279
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CTGF(1490)

描述

一般說明

Connective Tissue Growth Factor (CTGF) is a member of the CNN family of growth factors that are characterized as having cysteine-rich peptides with four specific domains. CTGF was originally identified in endothelial cells as a significant chemotactic and mitogenic factor. Research has revealed CTGF to have several biological properties which include chemotaxis, cell proliferation, promotion of adhesion and the formation of extracellular matrix. It is also necessary for such biological processes as wound healing, scar formation, fibrosis, embryogenesis and angiogenesis. In its role as an inducer of angiogenesis, CTGF has been associated with vascular endothelial growth factor (VEGF). As a result of its pro-fibrotic properties, CTGF is thought to be a promising target for therapy in conditions involving pathological fibrosis such as chronic fibrotic disease, chronic kidney disease and proliferative diabetic retinopathy (PDR). Cell types found to express CTGF are endothelial cells, fibroblasts and vascular smooth-muscle cells.

特異性

Primate (98% sequence homolgy). Monkey (97% sequence homology). Porcine and Bovine (93% sequence homology). Rat and mouse (91% sequence homology).

This antibody recognizes the mature chain of Connective tissue growth factor.

免疫原

Epitope: Mature chain

Recombinant protein corresponding to the mature chain of human Connective tissue growth factor.

應用

Anti-Connective Tissue Growth Factor Antibody detects level of Connective Tissue Growth Factor & has been published & validated for use in WB.

Research Category
Signaling

Research Sub Category
Growth Factors & Receptors

品質

Evaluated by Western Blot in untreated and TGFb1 treated NRK cell lysates.

Western Blot Analysis: 5 µg/mL of this antibody detected Connective tissue growth factor on 10 µg of untreated and TGFb1 treated NRK cell lysates.

標靶描述

In Western Blot, full length CTGF is observed at 38 kDa and CTGF N&C domain is observed at 19 kDa

外觀

Protein G Purified

Format: Purified

Purified goat polyclonal in buffer containing Tris-Glycine pH 8.0 with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Untreated and TGFb1 treated NRK cell lysates

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable