07-1378

Anti-QIK (SIK2) Antibody

Upstate^®, from rabbit

• 同義詞: Qin-induced kinase, SNF1-like kinase 2, Salt-inducible protein kinase 2, salt-inducible kinase 2, salt-inducible serine/threonine kinase 2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: rat, canine, mouse, chicken, bovine, human
• 製造商／商標名: Upstate^®
• 技術: western blot: suitable
• NCBI登錄號: NP_056006
• UniProt登錄號: Q9H0K1
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SIK2(23235)

描述

一般說明

QIK (Qin-induced Kinase, SNF1LK2, SIK2, Salt-induced protein Kinase 2) is a Ser/Thr kinase that belongs to the AMPK/SNF1 kinase family. QIK is phosphorylated and activated by the tumor suppressor LKB1 when in complex with the pseudokinase STRAD and the scaffolding protein MO25. QIK has been found in adipocytes where it is known to phosphorylate a few substrates that include insulin receptor substrate 1 (IRS1) on Ser794 and TORC2 (also known as CRTC2 and not to be confused with the mTOR complex) on Ser171. The phosphorylation of TORC2 results in its translocation to the nucleus where it binds to CREB.

特異性

Close homology with mouse, rat, chicken, dog, and cow.

Detects QIK

免疫原

KLH-conjugated synthetic peptide corresponding to the C-term of human QIK.

應用

Anti-QIK (SIK2) Antibody is an antibody against QIK (SIK2) for use in WB.

Research Category
Signaling

品質

Western Blot Analysis:
This lot detected QIK at 1:1,000-1:2,000 dilution in HeLa lysates via SDS-PAGE and transferred to PVDF (Immobilon-P).

標靶描述

104 kDa

外觀

Protein A purified

Format: Purified

Protein A purified rabbit serum in 0.1M Tris-Glycine (pH7.4) 15mM NaCl, and 0.05% NaN3 with 30% glycerol.

儲存和穩定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析報告

Control
HeLa Cell Lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1