07-068-I

Anti-Calcineurin A/PP2B catalytic unit Antibody

from rabbit, purified by affinity chromatography

• 同義詞: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit beta isoform
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human, rat, mouse
• 技術: immunoprecipitation (IP): suitable; western blot: suitable
• NCBI登錄號: NP_058738
• UniProt登錄號: P20651
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PPP3CA(5530) ; mouse ... Ppp3Ca(19055) ; rat ... Ppp3Ca(24674)

描述

一般說明

Calcineurin/PP2B Aβ, also known as Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, and encoded by the gene PPP3CB/CALNA2/CALNB/CNA2, is a calcium dependent, calmodulin stimulated catalytic subunit protein phosphatase critical in the function of Calcineurin an important phosphatase governing immune responses such as T cell activation and the T cell immune response. Calcineurin is a heterodimeric protein consisting of a catalytic subunit Calcineurin A, which contains an active site dinuclear metal center, and a tightly associated, myristoylated, Ca(2+)-binding subunit, Calcineurin B. Calcineurin/PP2B Aβ is the beta isoform of the catalytic active site of the subunit A of Calcineurin. Calcineurin also plays pivotal roles in signaling transduction cascades in a variety of other immune cells as well as non-immune cells like myocytes and neurons.

免疫原

Epitope: Near C-terminus

KLH-conjugated linear peptide corresponding to rat Calcineurin A/PP2B catalytic unit near the C-terminus.

應用

Immunoprecipitation Analysis: 5 µg from a representative lot immunoprecipitated Calcineurin A/PP2B catalytic unit in 500 µg of mouse brain tissue lysate.

Research Category
Signaling

Research Sub Category
Metabolic Hormones & Receptors

This Anti-Calcineurin A/PP2B catalytic unit antibody is validated for use in western blotting & IP for the detection of Calcineurin A/PP2B catalytic unit.

品質

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Calcineurin A/PP2B catalytic unit in 10 µg of human brain tissue lysate.

標靶描述

~57 kDa observed

聯結

Replaces: 07-068

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable