06-900

Anti-SynGAP Antibody

Upstate^®, from rabbit

• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: rat
• 製造商／商標名: Upstate^®
• 技術: immunocytochemistry: suitable; western blot: suitable
• NCBI登錄號: NM_006772.1
• UniProt登錄號: Q9QUH6
• 運輸包裝: dry ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SYNGAP1(8831)

描述

一般說明

Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.

特異性

SynGAP

免疫原

peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1289-1308 of rat SynGAP-a

應用

Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.

Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).

Research Category
Neuroscience

Research Sub Category
Synapse & Synaptic Biology

聯結

Replaces: 04-1071

外觀

Protein A purified

Format: Purified

Purified in PBS with 0.05% NaN3 and 30% Glycerol

儲存和穩定性

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2