05-1478

Anti-RUNX2 Antibody, clone AS110

clone AS110, from mouse

• 同義詞: Acute myeloid leukemia 3 protein, CBF-alpha 1, Core-binding factor subunit alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, PEA2-alpha A, PEBP2-alpha A, Polyomavirus enhancer-binding protein 2 alpha A subunit, SL3-3 enhancer factor 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: AS110, monoclonal
• 物種活性: human
• 技術: immunocytochemistry: suitable; western blot: suitable
• 同型: IgG2b
• NCBI登錄號: NP_001019801
• UniProt登錄號: Q13950
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... RUNX2(860)

描述

一般說明

RUNX2 (Runt-related transcription Factor) is a transcription factor that binds to its canonical consensus sequence 5’- PYGPYGGT-3’ in a number of promoters and enhancers. They include LCK, T-cell receptor enhancers, and various bone related genes such as osteocalcin, osteopontin, and bone sialoprotein. As a result of this, RUNX2 is involved in osteoblastic differentiation and skeletal morphogenesis. RUNX2 contains a proline/serine/ threonine-rich region at its C-terminus that has shown to be critical for its transcriptional activity.

特異性

Detects RUNX2

Other species have not been tested.

免疫原

Epitope: Internal

GST-coupled recombinant protein corresponding to amino acids 311-415 of human RUNX2.

應用

Anti-RUNX2 Antibody, clone AS110 detects level of RUNX2 & has been published & validated for use in WB & IC.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

品質

Routinely evaluated by Western Blot.

Western Blot Analysis:
Anti-RUNX2, clone AS110 detected RUNX at 1:1,000 to 1:2,000 dilution in HL-60 cell lysate resolved via SDS-PAGE and transferred to PVDF.

標靶描述

54-57 kDa

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal in 0.1M Tris-Glycine (pH 7.4) with 150mM NaCl and 0.05% NaN3.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable