04-1583

Anti-Interleukin 21 (IL-21) Antibody, clone 1G8

clone AB43.50.32H5.1G8, from mouse

• 同義詞: interleukin 2, interleukin-2, interleukin-21 isoform
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: AB43.50.32H5.1G8, monoclonal
• 物種活性: human
• 技術: ELISA: suitable; western blot: suitable
• 同型: IgG2aκ
• NCBI登錄號: NP_068575
• UniProt登錄號: Q9HBE4
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... IL21(59067)

描述

一般說明

Interleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin′s lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin′s lymphoma including clusters of other immune cells gathered around HL cells in cultures.

免疫原

Full length recombinant protein corresponding to human IL-21.

應用

ELISA Analysis: A previous lot was used by an independent laboratory in ELISA. (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX)

This Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 is validated for use in WB, ELISA for the detection of Interleukin 21 (IL-21).

品質

Evaluated by Western Blot from human IL-21 recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-21 on 10 µg of human IL-21 recombinant protein.

標靶描述

Two isoforms are observed at ~16 and ~18 kDa

外觀

Format: Purified

分析報告

Control
Human IL-21 recombinant protein

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable