推薦產品
等級
certified reference material
形狀
liquid
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
drug control
Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
濃度
1 mg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
clinical testing
格式
single component solution
儲存溫度
−20°C
SMILES 字串
Clc1ccc2NC(=O)CN=C(c3ccccc3)c2c1
InChI
1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
InChI 密鑰
AKPLHCDWDRPJGD-UHFFFAOYSA-N
一般說明
去甲西泮是一种苯二氮卓类药物，用于治疗焦虑症和恐慌症。该分析标准物质适用于LC/MS或GC/MS应用，以进行临床毒理学研究、法医分析或尿液药物检测。去甲西泮也是苯二氮卓类药物地西泮和氯氮卓的主要尿液代谢产物。
應用
- Probe Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantification of Benzodiazepines: This study employs advanced mass spectrometry techniques to enhance the detection and quantification of Nordiazepam and other benzodiazepines, critical for therapeutic drug monitoring in clinical settings. This method ensures high sensitivity and specificity, improving pharmacokinetic studies of benzodiazepine metabolites (Griffeuille et al., 2024).
- Selective Extraction of Diazepam and Its Metabolites from Urine Samples: Details a molecularly imprinted solid-phase extraction method, utilizing analytical grade Nordiazepam for benchmarking, to selectively extract diazepam and its metabolites from urine. This approach is pivotal for forensic and clinical toxicology, providing a reliable method for drug monitoring and abuse detection (Gil Tejedor et al., 2024).
- Hair Analysis in Postmortem Investigations: Discusses the application of hair analysis in forensic science, where Nordiazepam and other drug residues are identified in postmortem samples. This technique is essential for determining drug involvement in unexplained deaths, offering insights into chronic drug use or poisoning (Pelissier-Alicot et al., 2024).
- Diazepam: A comprehensive review of diazepam, detailing its pharmacology, therapeutic use, and metabolism, including Nordiazepam as a significant metabolite. This information is crucial for healthcare professionals to understand the effects, interactions, and potential side effects of this widely used benzodiazepine (2006).
- Trace Analysis of Psychotropic Medications in Environmental Samples: Utilizes ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) to detect low concentrations of Nordiazepam and other psychotropic medications in environmental samples. This research supports environmental health studies by tracking pharmaceutical pollutants, which can affect water sources and wildlife (Wang et al., 2024).
推薦產品
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
產品號碼
描述
訂價
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes,Central nervous system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Craig Lehmann et al.
Journal of clinical pharmacology, 48(4), 436-444 (2008-02-02)
A diazepam 10-mg autoinjector was evaluated in bioequivalence and dose proportionality studies; both involved 24 young, healthy subjects and used randomized, open-label, 2-treatment, 2-period crossover designs with a 3-week washout period between treatments. The bioequivalence study compared a single diazepam
Shanlin Fu et al.
Journal of analytical toxicology, 34(5), 243-251 (2010-06-10)
beta-Glucuronidase is an enzyme often employed to de-conjugate beta-glucuronides during urinary drug testing for benzodiazepines. It is commonly accepted that use of beta-glucuronidase is a preferred method of hydrolysis over acid-catalyzed hydrolysis, which is known to induce benzodiazepine degradation and
David A Fishbain et al.
Pain medicine (Malden, Mass.), 10(3), 565-572 (2008-11-11)
The objectives of this medicolegal case report are the following: 1) to present details of a chronic pain patient (CPP) who was placed on chronic opioid analgesic therapy (COAT), and subsequently overdosed on multiple drugs, some of which were not
Ali Acikgöz et al.
Toxicology and applied pharmacology, 234(2), 179-191 (2008-11-06)
Drug biotransformation is one of the most important parameters of preclinical screening tests for the registration of new drug candidates. Conventional existing tests rely on nonhuman models which deliver an incomplete metabolic profile of drugs due to the lack of
Joris C Verster et al.
Sleep medicine reviews, 17(2), 153-159 (2012-08-14)
The use of benzodiazepine receptor agonists can significantly impair driving performance. The aim of this review was to determine if there is a relation between blood concentrations of these drugs and the degree of driving impairment. A literature search was
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