D-115

Doxepin-D₃ (cis/trans) hydrochloride solution

1.0 mg/mL in methanol (as free base), certified reference material, Cerilliant^®

• 經驗公式（希爾表示法）: C₁₉H₁₈D₃NO · HCl
• CAS號碼: 347840-07-7
• 分子量：: 318.86
• MDL號碼: MFCD01074151
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329798673
• NACRES: NA.24

屬性

• 等級: certified reference material
• 品質等級: 300
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 1.0 mg/mL in methanol (as free base)
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: clinical testing
• 格式: single component solution
• 儲存溫度: −20°C
• SMILES 字串: CN(C([2H])([2H])[2H])CC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.[H]Cl
• InChI: 1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;/i1D3;
• InChI 密鑰: MHNSPTUQQIYJOT-JSMHCMNYSA-N

描述

一般說明

Doxepin is a tricyclic antidepressant used for the treatment of sleep maintenance. This internal standard is applicable for doxepin testing or isotope dilution methods by GC/MS or LC/MS for clinical toxicology, urine drug testing, or forensic analysis applications.

應用

• High-throughput protein precipitation method for doxepin analysis: A study presented a protein precipitation method using a 96-well plate to determine doxepin and nordoxepin levels in human plasma, employing LC-MS/MS, highlighting the utility of stable isotope-labeled doxepin for quantitative analysis in clinical settings (Margaryan et al., 2020).


• LC-MS-MS analysis of neuroleptics including doxepin: Research detailed the use of LC-MS-MS for analyzing neuroleptics like doxepin in hair samples from psychiatric patients, demonstrating the method′s effectiveness for long-term medication monitoring (Weinmann et al., 2002).


• Detection of doxepin in hair following therapy: A study investigated the detection of doxepin and its major metabolite in hair, providing a methodological foundation for forensic and clinical assessments of drug therapy adherence using hair samples (Negrusz et al., 1998).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup