B-067

(±)-Baclofen-D₄ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 經驗公式（希爾表示法）: C₁₀H₈D₄ClNO₂
• 分子量：: 217.69
• MDL號碼: MFCD21363459
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329773124
• NACRES: NA.24

屬性

• 等級: certified reference material
• 品質等級: 300
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 100 μg/mL in methanol
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: clinical testing
• 格式: single component solution
• 儲存溫度: −20°C

描述

一般說明

Baclofen, a derivative of gamma-aminobutyric acid (GABA), is a muscle relaxant used to treat spasticity. Marketed with brand names such as Kemstro, Lioresal or Gablofen, the drug has also shown effectiveness in the treatment of alcoholism. This certified solution standard is suitable for use as an internal standard in quantitative mass spectrometry-based testing applications in clinical toxicology, forensic analysis, pharmaceutical research or diagnostic testing.

應用

• Antidepressant Efficacy in Psychotherapy: Analyzes the effectiveness of combining antidepressants like O-Desmethylvenlafaxine with psychotherapy, enhancing therapeutic strategies for depression treatment (Alemi et al., 2024).


• Advanced Quantification Methods: Development of a multiplexed liquid chromatography-tandem mass spectrometry method for the quantification of Venlafaxine and its metabolites, including O-Desmethylvenlafaxine, crucial for precise pharmacokinetic studies in clinical settings (Pandey et al., 2024).


• Pharmacokinetic Modeling: Utilizes physiologically based pharmacokinetic modeling to explore the impact of CYP2D6 and CYP2C19 polymorphisms on Venlafaxine metabolism, crucial for understanding the role of O-Desmethylvenlafaxine in therapeutic efficacy and drug-gene interactions (Shen et al., 2024).


• Impact of Pharmacogenomics: Studies the influence of CYP2D6 phenotype on the pharmacokinetics of Venlafaxine in elderly patients, highlighting the importance of O-Desmethylvenlafaxine levels in optimizing antidepressant dosing (Men et al., 2024).


• Environmental Monitoring: Investigates the presence of pharmaceuticals, including O-Desmethylvenlafaxine, in surface waters under the EU Water Framework Directive, emphasizing the need for robust environmental surveillance and pollution control measures (Colzani et al., 2024).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup