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860843P

Avanti

18:0(2S-OH) Sulfo GalCer

Avanti Research - A Croda Brand 860843P, powder

同義詞:

3-O-sulfo-D-galactosyl-β1-1′-N-[2"(S)-hydroxystearoyl]-D-erythro-sphingosine (ammonium salt), (synthetic)

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About This Item

經驗公式(希爾表示法):
C42H84N2O12S
CAS號碼:
分子量::
841.19
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

powder

包裝

pkg of 1 × 1 mg (860843P-1mg)

製造商/商標名

Avanti Research - A Croda Brand 860843P

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC([C@@H](O)CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H]([C@H]1CO)O.[NH4+]

一般說明

18:0(2S-OH) Sulfo GalCer, also known as 3-O-sulfo-D-galactosyl-β1-1′-N-[2"(S)-hydroxystearyl]-D-erythro-sphingosine, is a sulfatide derived from 18:0(2S-OH) GalCer via esterification of a sulfate group to 3-hydroxyl of the galactose moiety. It is a vital constituent of the membranous myelin sheath.

生化/生理作用

Sulfatides or sulfo-galactosylceramide (S-GalCer) plays a vital role in protein trafficking, signal transduction and neuronal cell differentiation. Elevated levels of S-GalCer in lysosomes due to arylsulfatase A (ASA) deficiency leads to the development of metachromatic leukodystrophy in humans.

包裝

5 mL Amber Glass Screw Cap Vial (860843P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

閃點(°F)

No data available

閃點(°C)

No data available


分析證明 (COA)

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Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 116(2), 223-249 (2008)
Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 116(2), 223-249 (2008)
R Lüllmann-Rauch et al.
Histochemistry and cell biology, 116(2), 161-169 (2001-10-31)
The inherited deficiency of arylsulfatase A (ASA) causes lysosomal accumulation of sulfoglycolipids (mainly sulfo-galactosylceramide, S-GalCer ) and leads to metachromatic leukodystrophy in humans. Among visceral organs, kidneys are particularly affected. In the present study, the regional distribution and temporal development

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