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857128P

Avanti

0-油酰基-2-羟基-sn-甘油基-3-磷酸钠 钠盐

Avanti Research - A Croda Brand

同義詞:

1-十八烷酰基-sn-甘油-3-磷酸酯(钠盐);硬脂酰溶血磷脂酸; PA(18:0/0:0); 18:0 LPA; s-LPA; 110680

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About This Item

經驗公式(希爾表示法):
C21H42O7PNa
CAS號碼:
分子量::
460.52
分類程式碼代碼:
51191904
NACRES:
NA.25

描述

1-stearoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)

化驗

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

形狀

powder

包裝

pkg of 1 × 25 mg (857128P-25mg)

製造商/商標名

Avanti Research - A Croda Brand

脂質類型

cardiolipins
phospholipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

一般說明

溶血磷脂酸(1-或2-酰基溶血磷脂酸/LPA)是一种生物活性磷脂,血浆水平较低(~100 nM)。它通常在细胞膜磷脂合成过程中形成。它由多种细胞产生,如活化血小板、上皮细胞、白细胞、神经细胞和肿瘤细胞。18:0 Lyso PA在sn-1位有硬脂酸,在sn-2位有羟基。

應用

18:0 Lyso PA适用于:
  • 色谱法测定LPA中性pH和酸性pH条件下的提取回收率
  • 用作内标,研究肠源性溶血磷脂酸在血脂异常和动脉粥样硬化中的作用
  • 研究其对网格蛋白依赖性内吞作用的影响

生化/生理作用

溶血磷脂酸(1-或2-酰基溶血磷脂酸/LPA)可通过G蛋白偶联受体(GPCR)调节细胞运动、增殖、侵袭、存活和生长因子的产生。

包裝

5 mL棕色玻璃螺旋盖样品瓶(857128P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

也與該產品經常一起購買

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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存取文件庫

Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation, 2017 (2017)
Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis
Ailte I, et al.
Traffic, 18(3), 176-191 (2017)
Mohamad Navab et al.
Journal of lipid research, 54(12), 3403-3418 (2013-10-03)
We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic atherosclerosis in LDL receptor-null (LDLR⁻/⁻) mice fed a Western diet (WD). Here we demonstrate that WD increases unsaturated (but
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column
Shan L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864(1-2), 22-28 (2008)

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