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850546P

Avanti

MSDH

Avanti Research™ - A Croda Brand 850546P, powder

同義詞:

(S)-O-methyl-serine dodecylamide hydrochloride

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About This Item

經驗公式（希爾表示法）:
C16H35ClN2O2
CAS號碼:
2074614-60-9
分子量：:
322.91
分類程式碼代碼:
12161902
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

分子量

322.91 g/mol

包裝

pkg of 1 × 25 mg (850546P-25mg)

製造商／商標名

Avanti Research™ - A Croda Brand 850546P

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[NH3+][C@@H](COC)C(NCCCCCCCCCCCC)=O.[Cl-]

相關類別

一般說明

O-methyl-serine-dodecylamide hydrochloride (MSDH) is a synthetic lysosomotropic detergent.

應用

MSDH is suitable is suitable to induce lysosomal membrane destabilization to investigate the mechanistic basis for Bax/Bak-mediated autophagic cell death.

生化／生理作用

O-methyl-serine-dodecylamide hydrochloride (MSDH) stimulates cell death. After apoptosis, it may activate procaspase 3-like proteases and cause partial lysosomal rupture.

包裝

5 mL Amber Glass Screw Cap Vial (850546P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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分析證明 (COA)

Lot/Batch Number

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ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
Fucho R, et al.
Journal of Hepatology, 61(5), 1126-1134 (2014)
Ana M Villamil Giraldo et al.
Langmuir : the ACS journal of surfaces and colloids, 32(50), 13566-13575 (2016-12-13)
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in
Induction of cell death by the lysosomotropic detergent MSDH
Li W, et al.
Febs Letters, 470(1), 35-39 (2000)
Methylmercury and H2O2 provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
Dare E, et al.
Free radical biology & medicine, 30(12), 1347-1356 (2001)
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Karch J, et al.
eLife, 6, e30543-e30543 (2017)

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