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850446P

Avanti

14:0-18:0 PC

1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine, powder

同義詞:

1-十四烷酰基-2-十八烷酰基-sn-甘油-3-磷酰胆碱；MSPC；PC(14:0/18:0)

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About This Item

經驗公式（希爾表示法）:
C40H80NO8P
CAS號碼:
76343-22-1
分子量：:
734.04
分類程式碼代碼:
51191904
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 200 mg (850446P-200mg)
pkg of 1 × 25 mg (850446P-25mg)

製造商／商標名

Avanti Research™ - A Croda Brand 850446P

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)=O

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-19-20-21-23-25-27-29-31-33-40(43)49-38(37-48-50(44,45)47-35-34-41(3,4)5)36-46-39(42)32-30-28-26-24-22-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

InChI 密鑰

TYAQXZHDAGZOEO-KXQOOQHDSA-N

相關類別

一般說明

磷脂酰胆碱（PC）是结肠′粘膜层最重要的成分之一。14:0-18:0 PC（1-肉豆蔻酰基-2-硬脂酰基-sn-甘油-3-磷酸胆碱）是具有长烷基侧链的不对称脂质。

應用

14:0-18:0 PC（1-肉豆蔻酰基-2-硬脂酰基-sn-甘油-3-磷酸胆碱）可用于：
  • 脂质双层，采用差示扫描量热法（DSC）研究其与d-赤型-N-棕榈酰基-鞘磷脂（16:0-SM）的混溶性，
  • 作为脂质体中的不对称脂质成分，研究双层面积和脂质几何形状的影响，并作为脂质体增溶剂
  • 制备用于溶栓研究的低温敏感脂质体

生化／生理作用

磷脂酰胆碱（PC）通过充当表面活性剂在粘液中形成疏水表面，从而抑制细菌的渗透。

包裝

5 mL棕色玻璃螺旋盖小瓶（850446P-200mg）
5 mL棕色玻璃螺旋盖小瓶（850446P-25mg）

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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產品號碼
描述
訂價

儲存類別代碼

11 - Combustible Solids

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Joshua Owen et al.
Journal of controlled release : official journal of the Controlled Release Society, 319, 222-233 (2020-01-01)
The purpose of this exploratory study was to investigate the combination of a radiopharmaceutical, nanoparticles and ultrasound (US) enhanced delivery to develop a clinically viable therapeutic strategy for tumours overexpressing the epidermal growth factor receptor (EGFR). Molecularly targeted radionuclides have
Van Du Nguyen et al.
ACS applied materials & interfaces, 12(9), 10130-10141 (2020-02-12)
Although great efforts have been undertaken to develop a nanoparticle-based drug delivery system (DDS) for the treatment of solid tumors, the therapeutic outcomes are still limited. Immune cells, which possess an intrinsic ability to phagocytose nanoparticles and are recruited by
Bohdana Térová et al.
Biochimica et biophysica acta, 1667(2), 182-189 (2004-12-08)
In this study we have used differential scanning calorimetry (DSC) to study the miscibility of different saturated phosphatidylcholines (PCs) with D-erythro-N-palmitoyl-sphingomyelin (16:0-SM). Information about the miscibility was obtained by observing the thermotropic phase behavior of binary mixtures of saturated PCs
Li-Juan Zhao et al.
Journal of ethnopharmacology, 260, 112943-112943 (2020-05-19)
Arenobufagin (ArBu) is an important anti-tumor ingredient of Chan'su which has long been used as traditional Chinese medicine in clinic for tumor therapy in China. The purpose of our study is to investigate the lipid homeostasis regulation effects of ArBu
Simon Becher et al.
Analytical chemistry, 90(19), 11486-11494 (2018-09-11)
Phosphatidylcholines are the major phospholipid component of most eukaryotic cell membranes. Phosphatidylcholines have been shown to actively participate in regulatory and metabolic processes. Dysfunctional metabolic processes have been linked to human disease and can result in altered phosphatidylcholine structural features

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