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Key Documents

810218P

Avanti

C6-NBD鞘磷脂

Avanti Research - A Croda Brand 810218P, powder

同義詞:

2-脱氧6-[(7-硝基-2,-1,3-苯并恶二唑-4-基)氨基]-D-葡萄糖N-[6-[(7-硝基-2-1,3-苯并恶二唑-4-基l)氨基]己酰基]-鞘氨醇-1-磷酸胆碱

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About This Item

經驗公式(希爾表示法):
C35H61N6O9P
CAS號碼:
分子量::
740.87
分類程式碼代碼:
12352211
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (810218P-1mg)

製造商/商標名

Avanti Research - A Croda Brand 810218P

運輸包裝

dry ice

儲存溫度

−20°C

InChI

1S/C35H61N6O9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-21-32(42)30(28-49-51(46,47)48-27-26-41(2,3)4)37-33(43)22-19-17-20-25-36-29-23-24-31(40(44)45)35-34(29)38-50-39-35/h18,21,23-24,30,32,42H,5-17,19-20,22,25-28H2,1-4H3,(H2-,36,37,39,43,46,47)/b21-18+/t30-,32+/m0/s1

InChI 密鑰

YDBDYTGWMRUUSN-PERJAUJZSA-N

一般說明

鞘磷脂是具有中央鞘氨醇和酰胺连接的脂肪酸的膜磷脂。磷酸胆碱形成极性头基。它是乳脂肪球膜中的主要磷脂之一。

應用

C6-NBD鞘磷脂适用于内吞作用测定。

生化/生理作用

鞘磷脂控制细胞生长、分化、凋亡和沿膜的信号转导。已知其可防止结肠肿瘤的增殖。鞘磷脂还抑制胆固醇吸收。鞘磷脂的异常积累导致尼曼匹克病。

包裝

5 mL琥珀色玻璃螺旋盖小瓶(810218P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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The Journal of biological chemistry, 292(14), 5737-5747 (2017)
Mark L Schultz et al.
BMC medicine, 17(1), 200-200 (2019-11-13)
Niemann-Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body's endogenous cholesterol scavenging particle
Avery L McIntosh et al.
Lipids, 45(6), 465-477 (2010-05-18)
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