700078P

7α,25-dihydroxycholesterol-d6

Avanti Research^™ - A Croda Brand

• 同義詞: 26,26,26,27,27,27-hexadeutero-7α,25-dihydroxycholesterol ; 111117
• 經驗公式（希爾表示法）: C₂₇H₄₀D₆O₃
• CAS號碼: 2260669-11-0
• 分子量：: 424.69
• 分類程式碼代碼: 41141804
• NACRES: NA.25

屬性

• 描述: 7α,25-dihydroxycholesterol-d6
• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 1 mg (700078P-1mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H]

描述

一般說明

7α,25-dihydroxycholesterol (7α,25-OHC) is synthesized by the hydroxylation of cholesterol by the action of enzyme cholesterol 25-hydroxylase (CH25H) and cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1). The catabolic breakdown of 7α,25-OHC to bile acid precursors is catalyzed by the enzymes hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 (HSD3B7). 7α,25-dihydroxycholesterol-d6 is the deuterated form of 7α,25-dihydroxycholesterol.

應用

7α,25-dihydroxycholesterol-d6 has be used as an internal standard in liquid chromatography electrospray ionization tandem mass spectrometric (LC–ESI-MS/MS) analysis of human plasma.

生化／生理作用

7α,25-dihydroxycholesterol (7α,25-OHC) serves as an endogenous ligand for G-protein-coupled receptor 183 (GPR183) or Epstein-Barr virus-induced gene 2 (EBI2). It plays a key role in the migration of type 3 innate lymphoid cells (ILC3) in the small intestine and colon. 7α,25-OHC mediates immune cell migration functionality by their chemoattractant property. Inhibition of 7α,25-OHC synthesis leads to impairment in the migration of B cells.

包裝

5 mL Amber Glass Screw Cap Vial (700078P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 閃點（°F）: No data available
• 閃點（°C）: No data available