推薦產品
描述
cholest-5-ene-3β,25-diol-d6
化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 mg (700053P-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
25-羟基胆固醇（25HC）在氧气和胆固醇 25-羟化酶存在下由胆固醇合成，并且在 toll 样受体激活过程中转化依赖于烟酰胺腺嘌呤二核苷酸磷酸（NADPH）。25HC 分解代谢为 7α-羟基化甾醇。25-羟基胆固醇-d6 是 25-羟基胆固醇的氘代形式。
應用
25-羟基胆固醇-d6 在以下反应中用作内标：
- 通过液相色谱和串联质谱（LC-MS-MS） 法对空肠样品中的 25-OHC 进行定量
- 通过液相色谱-质谱法分析在血浆样品中
- 用于生成血浆氧甾醇定量的校准曲线
生化／生理作用
25-羟基胆固醇是一种肝脏 X 受体配体。这种生物活性脂质调节免疫反应和单核细胞的巨噬细胞产生。25-HC 作为抗病毒效应物，可能具有治疗潜力。它通过使甾醇调节元件结合蛋白失活并抑制 HMG-CoA 还原酶（HMGCR） 来减少胆固醇的生物合成。25-HC 可能通过抑制细胞凋亡和调节丝裂原活化蛋白激酶（MAPK） 通路在心肌缺血再灌注损伤中发挥保护作用。
包裝
5 mL 棕色玻璃螺旋盖样品瓶（700053P-1mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
閃點（°F）
No data available
閃點（°C）
No data available
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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