QBD10374

SPDP-dPEG^®₄-NHS ester

• 同義詞: 2,5-Dioxo-1-pyrrolidinyl 17-oxo-19-(2-pyridinyldithio)-4,7,10,13-tetraoxa-16-azanonadecanoate
• 經驗公式（希爾表示法）: C₂₃H₃₃N₃O₉S₂
• CAS號碼: 1334177-95-5
• 分子量：: 559.65
• MDL號碼: MFCD13185001
• 分類程式碼代碼: 12352108
• PubChem物質ID: 329823921
• NACRES: NA.22

屬性

• 化驗: >90%
• 形狀: solid or viscous liquid
• 反應適用性: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• 官能基: NHS ester
• 聚合物結構: shape: linear; functionality: heterobifunctional
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCSSC2=NC=CC=C2

描述

特點和優勢

SPDP-dPEG^®₄-NHS ester has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. Protein aggregation and precipitation also are greatly reduced with SPDP-dPEG crosslinkers compared to crosslinkers that have only hydrocarbon spacers. dPEG spacer of specific length (23.1 Å) provides precise distance control between the SPDP moiety and the target molecule. Pyridyldithiol reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT). Crosslinking experiments with SPDP reagents are not limited to those involving proteins. Any of a variety of molecules with primary amines and sulfhydryl groups can be modified or crosslinked using SPDP reagents.

法律資訊

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable