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Key Documents

H146

Sigma-Aldrich

4-羟基美芬妥英

≥98% (HPLC)

同義詞:

(±)-5-乙基-5-(4-羟苯基)-3-甲基海因, (±)-5-乙基-5-(4-羟苯基)-3-甲基羟基香豆素-2,4-二酮

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About This Item

經驗公式(希爾表示法):
C12H14N2O3
CAS號碼:
分子量::
234.25
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

≥98% (HPLC)

溶解度

DMSO: >5 mg/mL

SMILES 字串

CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2

InChI

1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)

InChI 密鑰

OQPLORUDZLXXPD-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

一般說明

美芬妥英的 YP2C19 代谢物。

應用

药理活性研究:
  • 药物对代谢的影响
  • 体外微粒体细胞色素P450活性

用于电子捕获气相色谱法的分析物

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Sonja Krösser et al.
European journal of clinical pharmacology, 62(4), 277-284 (2006-03-10)
The 5HT(1A) receptor agonist sarizotan is in clinical development for the treatment of dyskinesia, a potentially disabling complication in Parkinson's disease. We investigated the effect of sarizotan on the clinical pharmacokinetics of probe drugs for cytochrome P450 (CYP) to evaluate
M. Salsali, et al.,
Journal of Pharmacological and Toxicological Methods, 44, 461-465 (2001)
Xiao-Ping Chen et al.
Clinical pharmacology and therapeutics, 73(3), 264-271 (2003-03-07)
This study was designed to define the effect of low-dose aspirin administration on the activity of cytochrome P450 (CYP) in normal human subjects. Aspirin, 50 mg daily, was given for 14 days to 18 nonsmoking healthy male volunteers. A modified
J Caslavska et al.
Journal of chromatography. B, Biomedical applications, 656(1), 219-231 (1994-06-03)
Phenotypes for hydroxylation can be predicted by using mephenytoin and dextromethorphan as substrates, whereas phenotypes for acetylation can be determined with caffeine as probe drug. After single-dose administration of one of these drugs, of two of them simultaneously, or of
Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite.
M Bajpai et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(12), 1401-1403 (1996-12-01)

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