F6562

Fmoc-(R)-2-(7-octenyl)Ala-OH

for peptide synthesis

• 同義詞: (R)-N-Fmoc-α-(7-Octenyl)alanine, Fmoc-(R)-2-(7-octenyl)alanine, Fmoc-(R)-2-amino-2-methyl-dec-6-enoic acid
• 經驗公式（希爾表示法）: C₂₆H₃₁NO₄
• CAS號碼: 945212-26-0
• 分子量：: 421.53
• MDL號碼: MFCD12925761
• 分類程式碼代碼: 12352209
• PubChem物質ID: 329799756
• NACRES: NA.26

屬性

• 產品名稱: Fmoc-(R)-2-(7-octenyl)Ala-OH,
• 形狀: solid
• 品質等級: 200
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis
• 應用: peptide synthesis
• 官能基: Fmoc
• 儲存溫度: −20°C
• SMILES 字串: O=C(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)N[C@@](CCCCCCC=C)(C)C(O)=O
• InChI: 1S/C26H31NO4/c1-3-4-5-6-7-12-17-26(2,24(28)29)27-25(30)31-18-23-21-15-10-8-13-19(21)20-14-9-11-16-22(20)23/h3,8-11,13-16,23H,1,4-7,12,17-18H2,2H3,(H,27,30)(H,28,29)/t26-/m1/s1
• InChI 密鑰: MADFVGMQNXRFAF-AREMUKBSSA-N

描述

應用

Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.

安全資訊

• 象形圖: GHS09
• 訊號詞: Warning
• 危險聲明: H400
• 防範說明: P273 - P391 - P501
• 危險分類: Aquatic Acute 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable