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Key Documents

CDE-512

Sigma-Aldrich

Diether Liposomes

18:1 Diether PC:Cholesterol (70:30 molar ratio 1mM)

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About This Item

分類程式碼代碼:
12352211
NACRES:
NA.25

品質等級

成份

Phosphate buffered saline

濃度

1 mM

雜質

30 mol % Cholesterol
70 mol % 18:1 Diether PC

粒徑

100 nm

pH值

7.4

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一般說明

Liposomes are extensively used to study the interaction of proteins, peptides and other molecules with the surface of a lipid membrane. Ether lipids are a unique class of glycerophospholipids that have an alkyl chain attached to the sn-1 position by an ether bond.

Due to distinctive properties of ether lipids, liposomes made from ether lipids exhibit very unique characters and performance:
*ether bonds are more stable than ester linkages over a wide range of acidic or alkaline pH
*stability properties of the liposomes are enhanced by biopolar lipids and the saturated alkyl chains gives stability towards degradation in oxidative conditions
*the unusual stereochemistry of the glycerol backbone enhances the resistance against phopholipases

Due to their increased stability properties, ether liposomes are suitable candates for experiments that require an extended period of time as they can neither be hydrolyzed, oxidized, and can withstand higher temperatures.

應用

Drug delivery
Lipid-protein interactions

儲存和穩定性

Liposomes should never be frozen. Liposomes should be stored in the dark at 4°C, except when brought to room temperature for brief periods prior to use.

Liposomes are made under sterile conditions. If you need to take multiple aliquots out of the vial, it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size of liposomes particles.

法律資訊

Cellsome is a trademark of Encapsula NanoSciences
Product of Encapsula Nanosciences

免責聲明

For research use only

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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