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Key Documents

B1378

Sigma-Aldrich

2,6-二--丁基-4-甲基苯酚

≥99.0% (GC), powder

同義詞:

2,6-二-丁基甲酚, BHT, DBPC, 丁基化羟基甲苯, 丁基羟基甲苯

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About This Item

線性公式:
[(CH3)3C]2C6H2(CH3)OH
CAS號碼:
分子量::
220.35
Beilstein:
1911640
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

蒸汽密度

7.6 (vs air)

蒸汽壓力

<0.01 mmHg ( 20 °C)

化驗

≥99.0% (GC)

形狀

powder

自燃溫度

878 °F

bp

265 °C (lit.)

mp

69-73 °C (lit.)

溶解度

ethanol: 100 mg/mL
vegetable oils: soluble

SMILES 字串

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

InChI 密鑰

NLZUEZXRPGMBCV-UHFFFAOYSA-N

基因資訊

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應用

  • BHT及其过氧化物(BHTOOH)的热解特性:BHT具有优异的抗氧化性,在特定条件下分解为BHTOOH(S Dai, et al., 2024)。
  • 低应力聚合物网络的松弛机制:BHT被用于聚合物网络,评估其对牙科复合树脂的机械性能和耐久性的影响(SH Lewis, et al., 2024)。
  • 药品包装标签的相容性和安全性:研究发现标签中含有BHT,说明BHT因其稳定性广泛用于药品包装(C Fu, et al., 2023)。

生化/生理作用

二丁基羟基甲苯 (BHT) 是一种酚类抗氧化剂。它可以抑制脂类过氧化。它会导致小鼠肺部损伤以及促进肿瘤生长,这可能是由于 BHT 的代谢产物造成,即 6-叔丁基-2-[2′-(2′-羟基甲基)-丙基]-4-甲基苯酚。还报道了 BHT 的代谢产物会引起培养细胞中的 DNA 链断裂以及核小体间 DNA 断裂(细胞凋亡的典型特征)。向大鼠进行单次 BHT 腹腔注射(60mg/kg 体重)会引起肝、肾、心脏、脾、大脑和肺部的核 DNA 甲基转移酶活动的显著提高。用 BHT 孵育肺泡巨噬细胞可以显著降低 TNF-α 的含量,这可以解释该抗氧化剂缓解炎症的机理。用 BHT 预孵育经阿司匹林处理的血小板可以抑制由蛋白激酶 C 活化剂引起的分泌、聚集以及蛋白质磷酸化。BHT 还可抑制由黄曲霉素 B1 诱发的肝癌形成。

相關產品

產品號碼
描述
訂價

象形圖

Environment

訊號詞

Warning

危險聲明

防範說明

危險分類

Aquatic Acute 1 - Aquatic Chronic 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

260.6 °F - open cup

閃點(°C)

127 °C - open cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Nadja S Sieber-Ruckstuhl et al.
Scientific reports, 9(1), 6015-6015 (2019-04-14)
Glucocorticoids (GCs) are critical regulators of metabolic control in mammals and their aberrant function has been linked to several pathologies. GCs are widely used in human and veterinary clinical practice as potent anti-inflammatory and immune suppressive agents. Dyslipidaemia is a
A M Vijesh et al.
European journal of medicinal chemistry, 46(11), 5591-5597 (2011-10-05)
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized
Xiao-Juan Duan et al.
Journal of natural products, 70(7), 1210-1213 (2007-07-03)
Four new highly brominated and fully substituted mono- and bis-phenols, 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)pyrrolidin-2-one (1), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)ethane (2), 6-(2,3,6-tribromo-4,5-dihydroxybenzyl)-2,5-dibromo-3,4-dihydroxybenzyl methyl ether (3), and 2,3,6-tribromo-4,5-dihydroxybenzyl methyl sulfone (4), were characterized from the marine red alga Symphyocladia latiuscula. In addition, five known bromophenols, bis(2,3,6-tribromo-4,5-dihydroxyphenyl)methane (5), bis(2,3,6-tribromo-4,5-dihydroxybenzyl)
Gen-ichiro Arimura et al.
Plant physiology, 146(3), 965-973 (2008-01-01)
Continuous mechanical damage initiates the rhythmic emission of volatiles in lima bean (Phaseolus lunatus) leaves; the emission resembles that induced by herbivore damage. The effect of diurnal versus nocturnal damage on the initiation of plant defense responses was investigated using
Stefanie Engleitner et al.
International journal of oncology, 56(4), 1034-1044 (2020-04-23)
Metastatic cancer cells cross endothelial barriers and travel through the blood or lymphatic fluid to pre‑metastatic niches, leading to their colonisation. 'S' stereoisomer 12S‑hydroxy‑5Z,8Z,10E,14Z‑eicosatetraenoic acid [12(S)‑HETE] is secreted by a variety of cancer cell types and has been indicated to

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While quantitative analysis was performed for Vitamins D2 and D3, the samples were scanned for the presence of the 25-hydroxy metabolites.

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