934291

Thalidomide-O-amido-C₈-NH₂ trifluoroacetate

≥95.0%

• 同義詞: N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate
• 經驗公式（希爾表示法）: C₂₃H₃₀N₄O₆·C₂HF₃O₂
• CAS號碼: 1950635-16-1
• 分子量：: 572.53
• 分類程式碼代碼: 12352200
• NACRES: NA.21

屬性

• ligand: thalidomide
• 品質等級: 100
• 化驗: ≥95.0%
• 形狀: powder or crystals
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]

描述

應用

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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其他說明

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H301,H312,H360D
• 防範說明: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• 危險分類: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable